Risk stratification and outcomes of intracranial hemorrhage in patients with immune thrombocytopenia under 60 years of age
oleh: Peng Zhao, Ming Hou, Yi Liu, Hui-Xin Liu, Rui-Bin Huang, Hong-Xia Yao, Ting Niu, Jun Peng, Ming Jiang, Yan-Qiu Han, Jian-Da Hu, Hu Zhou, Ze-Ping Zhou, Lin Qiu, Lian-Sheng Zhang, Xin Wang, Hua-Quan Wang, Ru Feng, Lin-Hua Yang, Liang-Ming Ma, Shun-Qing Wang, Pei-Yan Kong, Wen-Sheng Wang, Hui-Ping Sun, Jing Sun, He-Bing Zhou, Tie-Nan Zhu, Li-Ru Wang, Jing-Yu Zhang, Qiu-Sha Huang, Xiao Liu, Hai-Xia Fu, Yue-Ying Li, Qian-Fei Wang, Qian Jiang, Hao Jiang, Jin Lu, Xiao-Hui Zhang
| Format: | Article |
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| Diterbitkan: | Taylor & Francis Group 2021-07-01 |
Deskripsi
Intracranial hemorrhage (ICH) is a devastating complication of immune thrombocytopenia (ITP). However, information on ICH in ITP patients under the age of 60 years is limited, and no predictive tools are available in clinical practice. A total of 93 adult patients with ITP who developed ICH before 60 years of age were retrospectively identified from 2005 to 2019 by 27 centers in China. For each case, 2 controls matched by the time of ITP diagnosis and the duration of ITP were provided by the same center. Multivariate analysis identified head trauma (OR = 3.216, 95%CI 1.296–7.979, P =.012), a platelet count ≤ 15,000/μL at the time of ITP diagnosis (OR = 1.679, 95%CI 1.044–2.698, P =.032) and severe/life-threatening bleeding (severe bleeding vs. mild bleeding, OR = 1.910, 95%CI 1.088–3.353, P =.024; life-threatening bleeding vs. mild bleeding, OR = 2.620, 95%CI 1.360–5.051, P =.004) as independent risk factors for ICH. Intraparenchymal hemorrhage (OR = 5.191, 95%CI 1.717–15.692, P =.004) and a history of severe bleeding (OR = 4.322, 95%CI 1.532–12.198, P =.006) were associated with the 30-day outcome of ICH. These findings may facilitate ICH risk stratification and outcome prediction in patients with ITP.