Identification of the S100 fused-type protein hornerin as a regulator of tumor vascularity
oleh: Michael F. Gutknecht, Marc E. Seaman, Bo Ning, Daniel Auger Cornejo, Emily Mugler, Patrick F. Antkowiak, Christopher A. Moskaluk, Song Hu, Frederick H. Epstein, Kimberly A. Kelly
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2017-09-01 |
Deskripsi
Angiogenesis is essential for solid tumor progression. Here, the authors interrogate the proteome of pancreatic cancer endothelium via phage display and identify hornerin as a critical protein whose expression is essential to maintain the pancreatic cancer vasculature through a VEGF-independent mechanism.