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Aim: To identify the etiology, incidence and prevalence of External ocular bacterial and fungal infections, and to assess the in-vitro antimicrobial susceptibility to the bacterial isolates. Material & Methods: This study include 125 patients with external ocular infections treated in the tertiary care hospitalChettinad Hospital and Research Institute, Chennai, India, between March 2011 to April 2012. The patients were examined by slit-lamp biomicroscopy, and then corneal scrapings, conjunctival swabs and purulent material were collected for cultures, smears and antibiotic sensitivity test by using standard protocols. Results: Out of 125 patients with external ocular infection, culture positivity was found in 80(64%) patients and rest of 45(36%) patients were culture negative. Among the 80(64%) culture positive patients, 45(56%) patients had conjunctival infections and 35(44%) had keratitis. From conjunctival infections - 49 bacterial isolates were recovered. The predominant bacterial isolate was found to be Coagulase negative Staphylococci 21(43%) followed by Staphylococcus aureus 12(24%). Among keratitis patients, 10(29%) patients had bacterial infection, 23(66%) patients had fungal infections and 2(5%)patients had mixed infections with bacteria and fungi. The predominant fungus was Fusarium species 12(48%) followed by Aspergillus flavus 6(24%). The gram positive isolates were susceptible to Vancomycin 100% followed by Ciprofloxacin 75%. Gram negative isolates were susceptible to Imipenam 100%, Amikacin 100% and Ciprofloxacin 96%. Conclusion: Coagulase negative Staphylococci frequently causes infection of the conjunctiva. Infections of the cornea due to filamentous fungi are a frequent cause of corneal damage in developing countries in the tropics and are difficult to treat.