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Periodontitis is a major public health concern because of its high prevalence and due to the significant impact on the masticatory function and aesthetics. Periodontitis can cause social inequality and greatly reduce quality of life. If a proper periodontal treatment is implemented, effective personal plaque management, and a thorough supportive phase, the majority of patients with periodontitis can preserve their natural teeth for an extended period of time. The subgingival mechanical instrumentation is the gold standard of periodontitis treatment and it determines a significant change in the subgingival microbiota. Due to the fact that in some clinical situations subgingival instrumentation is not totally efficient different locally delivered antibiotics can be used as adjunctive therapies to periodontitis treatment. The present article aims to provide information with respect to some locally delivered antibiotics used as adjunctive therapy in periodontitis treatment.