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The conventional foaming agents have the problems of poor adaptability and high cost during the application in different types of gas fields, especially in high temperature, high salinity, high acidic gas and high condensate oil and gas fields. In this study, the Gemini foaming agent was used as the main agent to enhance foaming and foam stability of the foaming agent, the grafted nanoparticles were used as foam stabilizer to further improve the foam stability, and the characteristic auxiliaries were added to make the foaming agent suitable for different types of gas reservoirs. Two types and six subtypes of nanoparticle foaming agents have been prepared for the main gas fields of China. The experimental evaluation results show that the overall temperature resistance, salinity resistance, H2S resistance, CO2 resistance and condensate resistance of the nanoparticle foaming agents can reach 160°C, 250 000 mg/L, 100 mg/L, 100% and 40%, respectively. The new foaming agents have been used in 8685 wells in China. Compared with conventional foaming agent, the average gas flow rate per well increased by 62.48%, the pressure difference (casing-tubing) decreased by 18.9%, and the cost dropped by 45%. The effect of reducing cost and increasing efficiency is obvious. Key words: water-yielding gas well, Gemini surfactant, nano-particle, characteristic auxiliaries, foaming agents series, drainage gas recovery