Dissecting esophageal squamous-cell carcinoma ecosystem by single-cell transcriptomic analysis
oleh: Xiannian Zhang, Linna Peng, Yingying Luo, Shaosen Zhang, Yang Pu, Yamei Chen, Wenjia Guo, Jiacheng Yao, Mingming Shao, Wenyi Fan, Qionghua Cui, Yiyi Xi, Yanxia Sun, Xiangjie Niu, Xuan Zhao, Liping Chen, Yuqian Wang, Yachen Liu, Xinyu Yang, Chengcheng Wang, Ce Zhong, Wen Tan, Jianbin Wang, Chen Wu, Dongxin Lin
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2021-09-01 |
Deskripsi
Esophageal squamous-cell carcinomas (ESCC) have poor prognosis, and detailed molecular profiles are necessary to identify prognostic markers. Here the authors analyse 60 ESCC patient samples using scRNA-seq, TCR-seq and genomics; they find mucosal immunity markers associated with survival and immunosuppressive microenvironments.