Polyamide-scorpion cyclam lexitropsins selectively bind AT-rich DNA independently of the nature of the coordinated metal.
oleh: Anthony T S Lo, Noeris K Salam, David E Hibbs, Peter J Rutledge, Matthew H Todd
| Format: | Article |
|---|---|
| Diterbitkan: | Public Library of Science (PLoS) 2011-05-01 |
Deskripsi
Cyclam was attached to 1-, 2- and 3-pyrrole lexitropsins for the first time through a synthetically facile copper-catalyzed "click" reaction. The corresponding copper and zinc complexes were synthesized and characterized. The ligand and its complexes bound AT-rich DNA selectively over GC-rich DNA, and the thermodynamic profile of the binding was evaluated by isothermal titration calorimetry. The metal, encapsulated in a scorpion azamacrocyclic complex, did not affect the binding, which was dominated by the organic tail.