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Objective: This study aimed to compare psychological capital and metacognitive beliefs between drug-dependent students and normal students. Method: The present study was of a causal-comparative nature. The students of Azad University of Tabriz in 2013 constituted the study population. Then, two groups of 50 drug-dependent and normal students were selected through convenience and clustering sampling methods, respectively. Cartwright-Hatton and Wells’ Metacognitions Questionnaire (MCQ-30) and Luthans’ Psychological Capital Questionnaire (PCQ-24) were used for data collection purposes. Results: The results showed that there was a statistically significant difference between the two groups in terms of psychological capital and metacognitive beliefs. This means that drug-dependent students suffer lower psychological capital and impaired metacognitive beliefs. Conclusion: According to the obtained results, it is feasible to wane students’ tendency to drug use with the growth of psychological capital and the implementation of programs on metacognitive beliefs.