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The microRNA is a kind of small non-coding RNA, which can cause target mRNA degradation or translation inhibition. Reactive oxygen species(ROS)represent the main active product of redox. It has been reported that ROS are involved in different signaling pathways to keep cell stability. The imbalance of ROS in cell is closely related to tumorigenesis. In the progress of occurrence and development of human glioma, microRNAs and ROS can affect cell proliferation, apoptosis, invasion, migration, and resistance to chemotherapy as well as radiotherapy. Therefore, to understand the mechanism of miRNA on ROS may lead to a potential strategy for glioma treatment.