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In this historical moment, the challenge facing psychology is to guarantee people’s psychological well-being and to promote resilience. In line with this scientific purpose, the contributions published in this issue of the JCDP have as their common focus the role that the quality of life plays for the individual’s mental and physical well-being, both in the presence and absence of pathology. This issue provides the opportunity to reflect on the need to implement methods and techniques aimed at promoting the individual adjustment in different contexts during the course of his life.