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During this interview, Catherine Cailloux Teiger, a leader in French ergonomics, tells how, when she joined the CNAM Laboratoire d’ergonomie et de physiologie du travail, she discovered this new discipline that was in the process of being developed. We learn that with her first field research studies, her constant concern about creating and developing data collection methods that reveal the actual work activity was already present. This account about decades of research work scans a large spectrum of often original research questions such as women’s work, attrition in the workplace, ageing in the workplace, and the differential morbidity and mortality between various manual labour categories, despite an apparent homogeneity of status. The interview ends with reflection on the current trends intersecting the discipline and on the practice of French ergonomics.