Sex differences in the percentage of IRF5 positive B cells are associated with higher production of TNF-α in women in response to TLR9 in humans
oleh: Claudia Beisel, Ana Jordan-Paiz, Sandra Köllmann, Annika Elise Ahrenstorf, Benedetta Padoan, Tanja Barkhausen, Marylyn M. Addo, Marcus Altfeld
| Format: | Article |
|---|---|
| Diterbitkan: | BMC 2023-02-01 |
Deskripsi
Highlights Women showed higher percentage of IRF5 positive B cells compared to men. After stimulation with a TLR7 or TLR9 agonist, women showed higher percentages of IRF5 positive B cells compared with those of men. B cells of women produced higher levels of TNF-α in response to TLR9 stimulation. IRF5 represents a potential therapeutic target to reduce harmful B cell-mediated immune responses in women.