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Changes in soil properties and processes can influence food and environmental quality, thus, affecting human health and welfare through biogeochemical cascades among soil, food, environment, and human health. However, because many soil properties change much more slowly than do management practices and pollution to soil, the legacy of past influences on soil can have long-term effects on both human health and sustainability. It is essential and urgent to manage soils for health and sustainability through building the soil-food-environment-health nexus.