Colonization and genetic diversification processes of Leishmania infantum in the Americas
oleh: Philipp Schwabl, Mariana C. Boité, Giovanni Bussotti, Arne Jacobs, Bjorn Andersson, Otacilio Moreira, Anita L. Freitas-Mesquita, Jose Roberto Meyer-Fernandes, Erich L. Telleria, Yara Traub-Csekö, Slavica Vaselek, Tereza Leštinová, Petr Volf, Fernanda N. Morgado, Renato Porrozzi, Martin Llewellyn, Gerald F. Späth, Elisa Cupolillo
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2021-01-01 |
Deskripsi
Philipp Schwabl, Mariana Boité, and colleagues analyze 126 Leishmania infantum genomes to determine how demographic and selective consequences of the parasite’s invasive history have contributed to intricate population genetic heterogeneity across Brazil. Their data suggest a complex interplay of population expansion, secondary contact and genetic exchange events underlying diversity patterns at short and long-distance scales. These processes also appear pivotal to the proliferation of a drug resistance-associated multi-gene deletion on chromosome 31.