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Two new neolignans jatrolignans, C (<b>1</b>) and D (<b>2</b>), a pair of epimers, were isolated from the whole plants of <i>Jatropha c</i><i>urcas</i> L. (Euphorbiaceae). Their structures were determined with HRESIMS, IR, and NMR data analysis, and electronic circular dichroism (ECD) experiments via a comparison of the experimental and the calculated ECD spectra. Their antichlamydial activity was evaluated in <i>Chlamydia abortus.</i> They both showed dose-dependent antichlamydial effects. Significant growth inhibitory effects were observed at a minimum concentration of 40 μM.