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Cadmium accumulation in wheat as a daily food, even in low concentrations, is a serious threat to human health. Previous studies have reported conflicting results on the impact of calcium treatments on cadmium uptake and translocation in plants due to the complex soil conditions. Our hydroponic study offers clearer insights into how specific calcium treatment parameters influence cadmium uptake and translocation in wheat. The hydroponic medium was contaminated by cadmium (CdCl₂) and the following treatments were applied: CaCO₃, CaSO₄, CaCl₂, CaCO₃ + CaSO₄, CaCO₃ + CaCl₂, and CaSO₄ + CaCl₂. After harvesting, the wheat was analyzed for Cd²⁺ uptake characteristics including translocation factor, bioconcentration factor, and uptake. Furthermore, physiological growth parameters and plant nutrients were also determined. Applying CaCO₃ significantly decreased wheat Cd²⁺ concentration by about three times in CaCO₃ and two times in CaCO₃ + CaSO₄ and CaCO₃ + CaCl₂ treatments than in Cd-control. This study clearly elucidates that pH and CO₃²⁻ were crucial in reducing Cd²⁺ concentration in wheat. SO₄²⁻, Cl⁻, and Ca²⁺ showed no effect on Cd²⁺ concentration. Ca²⁺ only reduced the translocation factor (TF) of Cd²⁺ in plants. CaCO₃ also declined cadmium interference in the Mg²⁺, Mn²⁺, and Cu²⁺ uptake. Therefore, this study provides novel insight into the pure effects of calcium treatments on controlling cadmium contamination in plants, independent of soil effect.