Cis interaction between sialylated FcγRIIA and the αI-domain of Mac-1 limits antibody-mediated neutrophil recruitment
oleh: Gurpanna Saggu, Koshu Okubo, Yunfeng Chen, Ravi Vattepu, Naotake Tsuboi, Florencia Rosetti, Xavier Cullere, Nathaniel Washburn, Suhail Tahir, Aaron M. Rosado, Steven M. Holland, Robert M. Anthony, Mehmet Sen, Cheng Zhu, Tanya N. Mayadas
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2018-11-01 |
Deskripsi
Deposited immune complexes (IC) promote neutrophil recruitment, but the fine tuning of this process is still unclear. Here the authors show that the cis interaction of the IC receptor, FcγRIIA and CD18 integrin, Mac-1, on the neutrophil surface modulates neutrophil adhesion, with FcγRIIA sialylation specifically implicated in this interaction.