Heart enhancers with deeply conserved regulatory activity are established early in zebrafish development

mā: Xuefei Yuan, Mengyi Song, Patrick Devine, Benoit G. Bruneau, Ian C. Scott, Michael D. Wilson

Hōputu: Article
I whakaputaina: Nature Portfolio 2018-11-01

Whakaahuatanga

During early embryogenesis, critical cardiac specification events occur. Here the authors isolate cardiac progenitor cells from early zebrafish embryos and characterize accessible chromatin regions specific to this cell population, finding that many of these regions overlap with conserved non-coding elements that are ortholgous to accessible chromatin regions in human.