Population Bottlenecks and Intra-host Evolution During Human-to-Human Transmission of SARS-CoV-2
por: Daxi Wang, Daxi Wang, Yanqun Wang, Wanying Sun, Wanying Sun, Wanying Sun, Lu Zhang, Lu Zhang, Jingkai Ji, Jingkai Ji, Zhaoyong Zhang, Xinyi Cheng, Xinyi Cheng, Xinyi Cheng, Yimin Li, Fei Xiao, Airu Zhu, Bei Zhong, Shicong Ruan, Jiandong Li, Jiandong Li, Jiandong Li, Peidi Ren, Peidi Ren, Zhihua Ou, Zhihua Ou, Minfeng Xiao, Minfeng Xiao, Min Li, Min Li, Min Li, Ziqing Deng, Ziqing Deng, Huanzi Zhong, Huanzi Zhong, Huanzi Zhong, Fuqiang Li, Fuqiang Li, Fuqiang Li, Wen-jing Wang, Wen-jing Wang, Yongwei Zhang, Weijun Chen, Weijun Chen, Shida Zhu, Shida Zhu, Xun Xu, Xun Xu, Xin Jin, Jingxian Zhao, Nanshan Zhong, Wenwei Zhang, Jincun Zhao, Jincun Zhao, Junhua Li, Junhua Li, Junhua Li, Yonghao Xu
| Formato: | Article |
|---|---|
| Publicado em: | Frontiers Media S.A. 2021-02-01 |
Descrição
The emergence of the novel human coronavirus, SARS-CoV-2, causes a global COVID-19 (coronavirus disease 2019) pandemic. Here, we have characterized and compared viral populations of SARS-CoV-2 among COVID-19 patients within and across households. Our work showed an active viral replication activity in the human respiratory tract and the co-existence of genetically distinct viruses within the same host. The inter-host comparison among viral populations further revealed a narrow transmission bottleneck between patients from the same households, suggesting a dominated role of stochastic dynamics in both inter-host and intra-host evolutions.