Maternal Carriage in Late-Onset Group B Streptococcus Disease, Italy
oleh: Alberto Berardi, Caterina Spada, Roberta Creti, Cinzia Auriti, Lucia Gambini, Vittoria Rizzo, Mariagrazia Capretti, Nicola Laforgia, Irene Papa, Anna Tarocco, Angela Lanzoni, Giacomo Biasucci, Giancarlo Piccinini, Giovanna Nardella, Giuseppe Latorre, Daniele Merazzi, Laura Travan, Maria Letizia Bacchi Reggiani, Lorenza Baroni, Matilde Ciccia, Laura Lucaccioni, Lorenzo Iughetti, Licia Lugli
| Format: | Article |
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| Diterbitkan: | Centers for Disease Control and Prevention 2021-09-01 |
Deskripsi
We retrospectively investigated mother-to-infant transmission of group B Streptococcus (GBS) in 98 cases of late-onset disease reported during 2007–2018 by a network in Italy. Mothers with full assessment of vaginal/rectal carriage tested at prenatal screening and at time of late onset (ATLO) were included. Thirty-three mothers (33.7%) were never GBS colonized; 65 (66.3%) were vaginal/rectal colonized, of which 36 (36.7%) were persistently colonized. Mothers with vaginal/rectal colonization ATLO had high rates of GBS bacteriuria (33.9%) and positive breast milk culture (27.5%). GBS strains from mother–infant pairs were serotype III and possessed the surface protein antigen Rib. All but 1 strain belonged to clonal complex 17. GBS strains from 4 mother–infant pairs were indistinguishable through pulsed-field gel electrophoresis. At least two thirds of late-onset cases are transmitted from mothers, who often have vaginal/rectal carriage, positive breast milk culture, or GBS bacteriuria, which suggests heavy maternal colonization.