CD4 derived double negative T cells prevent the development and progression of nonalcoholic steatohepatitis
oleh: Guangyong Sun, Xinyan Zhao, Mingyang Li, Chunpan Zhang, Hua Jin, Changying Li, Liwei Liu, Yaning Wang, Wen Shi, Dan Tian, Hufeng Xu, Yue Tian, Yongle Wu, Kai Liu, Zhongtao Zhang, Dong Zhang
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2021-01-01 |
Deskripsi
Hepatic inflammation contributes to the development of nonalcoholic steatohepatitis (NASH). Here, the authors show that a transfer of ex vivo generated CD4 derived double negative T cells can prevent the development and progression of NASH by suppression of inflammatory Th17 cells and M1 macrophages in mouse models.