Blocking TNF in vitro with infliximab determines the inhibition of expansion and interferon gamma production of Vγ9/Vδ2 T lymphocytes from patients with active rheumatoid arthritis. A role in the susceptibility to tuberculosis?
oleh: A. Principato, A. Ferrante, F. Ciccia, A. Accardo-Palumbo, A.R. Giardina, R. Impastato, G. Triolo
| Format: | Article |
|---|---|
| Diterbitkan: | PAGEPress Publications 2011-06-01 |
Deskripsi
Biological therapeutic agents neutralising tumour necrosis factor (TNF) are highly active in treating chronic inflammatory diseases, such as Crohn’s disease, rheumatoid arthritis, ankylosing spondylitis, uveitis, and psoriasis (1-3). From the beginning, side effects of TNF neutralisation - mostly infectious complications - were recognized, the most important being, however, pulmonary tuberculosis infections (4).