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Hirayama disease (HD) or monomelic amyotrophy (MA) is a rare muscular atrophy that affects young Asian males, usually occurs in one of the upper limbs that progresses slowly. It is diagnosed by means of electromyographic/electroneurographic conduction speed studies and by magnetic resonance imaging (MRI) of the spinal cord. In this paper two different HD case is reported. [Med-Science 2017; 6(3.000): 560-1]