Parallel functional assessment of m6A sites in human endodermal differentiation with base editor screens
oleh: Weisheng Cheng, Fang Liu, Zhijun Ren, Wenfang Chen, Yaxin Chen, Tianwei Liu, Yixin Ma, Nan Cao, Jinkai Wang
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2022-01-01 |
Deskripsi
N6-methyladenosine (m6A) plays important role in lineage specifications of embryonic stem cells, but its role at specific sites has not been assessed. Here the authors develop an adenine editor-based strategy, and systematically identify functional m6A sites that control lineage decisions in human embryonic stem cells.