BAF60a deficiency uncouples chromatin accessibility and cold sensitivity from white fat browning
oleh: Tongyu Liu, Lin Mi, Jing Xiong, Peter Orchard, Qi Yu, Lei Yu, Xu-Yun Zhao, Zhuo-Xian Meng, Stephen C. J. Parker, Jiandie D. Lin, Siming Li
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2020-05-01 |
Deskripsi
The regulatory networks that govern chromatin accessibility and gene expression in brown and beigeadipocytes remain to be fully elucidated. Here the authors use fat-specific inactivation of BAF60a toreveal a differential role for this chromatin remodeling factor in brown fat thermogenesis and coldinduced browning of inguinal fat.