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Periprosthetic joint infection (PJI) is one of the most dreaded complications following total knee arthroplasty (TKA). Even though the incidence is low following TKA, it still constitutes a large number of cases due to increasing rates of TKA. Two-stage revision TKA using a prefabricated antibiotic-impregnated articulating methyl-methacrylate spacer offers eradication of infection along with the additional advantage of improved interval/postrevision function and range of motion compared to custom-made/static spacers and should be considered the treatment of choice for chronic PJI.