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Leveraging Immunopeptidomics To Study and Combat Infectious Disease
oleh: Owen K. Leddy, Forest M. White, Bryan D. Bryson
Format: | Article |
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Diterbitkan: | American Society for Microbiology 2021-08-01 |
Deskripsi
T cells must recognize pathogen-derived peptides bound to major histocompatibility complexes (MHCs) in order to initiate a cell-mediated immune response against an infection, or to support the development of high-affinity antibody responses. Identifying antigens presented on MHCs by infected cells and professional antigen-presenting cells (APCs) during infection may therefore provide a route toward developing new vaccines.