Leveraging Immunopeptidomics To Study and Combat Infectious Disease

oleh: Owen K. Leddy, Forest M. White, Bryan D. Bryson

Format: Article
Diterbitkan: American Society for Microbiology 2021-08-01

Deskripsi

T cells must recognize pathogen-derived peptides bound to major histocompatibility complexes (MHCs) in order to initiate a cell-mediated immune response against an infection, or to support the development of high-affinity antibody responses. Identifying antigens presented on MHCs by infected cells and professional antigen-presenting cells (APCs) during infection may therefore provide a route toward developing new vaccines.