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6-Methylideneandrost-4-ene-3,17-dione
oleh: L. C. R. Andrade, M. J. M. de Almeida, F. M. Fernandes Roleira, C. L. Varela, E. J. Tavares da Silva
Format: | Article |
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Diterbitkan: | International Union of Crystallography 2012-04-01 |
Deskripsi
In the title compound, C20H26O2, which is the 6-methylene derivative of androstenedione and a synthetic percursor of exemestane, the steroid A ring approximates to a sofa (or envelope) conformation, with the methylene group adjacent to the link to the B ring lying out of the plane of the other atoms. The B and C rings have slightly flattened chair conformations and the D ring is an envelope, with the CH group forming the flap. In the crystal, molecules are linked by two distinct C—H...O hydrogen bonds, involving acidic H atoms close to C=C and C=O double bonds.