The ABCG2 multidrug transporter is a pump gated by a valve and an extracellular lid

oleh: Narakorn Khunweeraphong, Daniel Szöllősi, Thomas Stockner, Karl Kuchler

Format: Article
Diterbitkan: Nature Portfolio 2019-11-01

Deskripsi

The human ATP-binding cassette transporter ABCG2 plays critical roles in anticancer resistance but the molecular mechanism of ABCG2-mediated substrate transport remains enigmatic. Here authors use extensive mutagenesis and molecular dynamics simulations to reveal a mechanistic basis for the function of the di-leucine valve and the roof organization in the transport cycle.