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The ABCG2 multidrug transporter is a pump gated by a valve and an extracellular lid
oleh: Narakorn Khunweeraphong, Daniel Szöllősi, Thomas Stockner, Karl Kuchler
Format: | Article |
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Diterbitkan: | Nature Portfolio 2019-11-01 |
Deskripsi
The human ATP-binding cassette transporter ABCG2 plays critical roles in anticancer resistance but the molecular mechanism of ABCG2-mediated substrate transport remains enigmatic. Here authors use extensive mutagenesis and molecular dynamics simulations to reveal a mechanistic basis for the function of the di-leucine valve and the roof organization in the transport cycle.