Topoisomerase 2β Induces DNA Breaks To Regulate Human Papillomavirus Replication
oleh: Paul Kaminski, Shiyuan Hong, Takeyuki Kono, Paul Hoover, Laimonis Laimins
| Format: | Article |
|---|---|
| Diterbitkan: | American Society for Microbiology 2021-02-01 |
Deskripsi
High-risk human papillomaviruses (HPVs) infect epithelial cells and induce viral genome amplification upon differentiation. HPV proteins activate DNA damage repair pathways by inducing high numbers of DNA breaks in both viral and cellular DNAs.