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The combination of topology optimization (TO) and 3D printing has revolutionized the way components are designed and fabricated. In view of this, this manuscript presents a TO workflow considering the frame of a scooter. In particular, TO is employed to redesign the scooter frame based on a commercial one. The topologically optimized frame is then fabricated with stainless steel 316L utilizing the selective laser melting (SLM) method. In particular, technical obstacles encountered during the process and according solutions are recorded. Given the herein notes, readers who are working with the two technologies can anticipate the technical problems and deliver more effective solutions should any of them arise.