Reconciled rat and human metabolic networks for comparative toxicogenomics and biomarker predictions
oleh: Edik M. Blais, Kristopher D. Rawls, Bonnie V. Dougherty, Zhuo I. Li, Glynis L. Kolling, Ping Ye, Anders Wallqvist, Jason A. Papin
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2017-02-01 |
Deskripsi
The rat is a widely-used model for human biology, but we must be aware of metabolic differences. Here, the authors reconstruct the genome-scale metabolic network of the rat, and after reconciling it with an improved human metabolic model, demonstrate the power of the models to integrate toxicogenomics data, providing species-specific biomarker predictions in response to a panel of drugs.