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New simple sensitive spectrophotometric methods are developed for determination of cefepime (CFM) in pure and Pharmaceutical Formulations. The first method conversion primary amine to azo-dye by react cefepime with sodium nitrite and hydrochloric acid followed by coupling with 3-aminophenol in alkaline medium to obtain a stable orange colored dye at λ max 495 nm. The concentration ranges 2–50 μg / mL, Beer's law is obeyed, correlation coefficient was 0.9997, molar absorptivity was 0.704 × 104L.mol−1.cm−1 and the detection limit was 0.259 μg/mL. Cloud point extraction (CPE) second method to estimation a trace amount in aqueous solution product from diazotization and measuring with a UV–visible spectrophotometer at λ max 495 nm. The concentration range obeyed the Beer's law was 0.25–10 μg / mL, correlation coefficient was 0.9996, molar absorptivity was 1.362 × 105L.mol−1.cm−1, detection limit was 0.013 μg/mL, Pre-concentration factor was 25 and Distribution coefficient(D) was 333.35.