R-spondin 3 promotes stem cell recovery and epithelial regeneration in the colon
oleh: Christine Harnack, Hilmar Berger, Agne Antanaviciute, Ramon Vidal, Sascha Sauer, Alison Simmons, Thomas F. Meyer, Michael Sigal
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2019-09-01 |
Deskripsi
Epithelial turnover in the colon requires stem cells in the crypt that express the R-spondin receptor Lgr5. Here, the authors show that regeneration after colon injury involving loss of Lgr5+ and Axin2+ cells requires stromal derived Rspo3-dependent reprogramming of Lgr4+ differentiated cells, including Krt20+ enterocytes.