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<p><strong></strong>We present here a case of cough, expectoration and fever for six days. After investigation by the doctor and epidemiologist, it was confirmed that this patient had a history of contact with a novel influenza virus. All the results of the real time PCR on novel Swine Influenza H1 were positive. Blood-gas assay PO250.6 mmHg, hypoxemia and computed tomography (CT) of lungs indicated patchy dense shadow scattered in both lungs in which the inflatable bronchial shadow was observed. A visible change in leakage around the shadow was seen. This was a serious case of infection from a novel influenza virus and the patient received systemic treatment: oseltamivir 75mg bid po, methylprednisolone 40mg qd iv, biapenem 0.6 q12h iv, and moxifloxacin 0.4qd po. On discharge from hospital, Swine influenza H1 was negative. Lungs showed apparent absorption of the inflammation. Respiratory failure had been corrected. Patients infected with a novel influenza virus should be given low-dose hormone and an antiviral drug as soon as possible after the infection is confirmed.</p>