TRIM66 reads unmodified H3R2K4 and H3K56ac to respond to DNA damage in embryonic stem cells
oleh: Jiajing Chen, Zikang Wang, Xudong Guo, Fudong Li, Qingtao Wei, Xuwen Chen, Deshun Gong, Yanxin Xu, Wen Chen, Yongrui Liu, Jiuhong Kang, Yunyu Shi
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2019-09-01 |
Deskripsi
TRIM66 protein has an N-terminal tripartite motif and a C-terminal PHD Bromodomain. Here the authors show the specific histone modification recognition of TRIM66-PHD-Bromodomain through crystallography and biochemistry assay, and further reveal that TRIM66 recognition of certain histone modification is important for DNA damage repair in ESCs.