Overweight and Obesity Are Associated With Acute Kidney Injury and Acute Respiratory Distress Syndrome, but Not With Increased Mortality in Hospitalized COVID-19 Patients: A Retrospective Cohort Study

oleh: Jamie van Son, Sabrina M. Oussaada, Aydin Şekercan, Martijn Beudel, Dave A. Dongelmans, Sander van Assen, Ingo A. Eland, Hazra S. Moeniralam, Tom P. J. Dormans, Colin A. J. van Kalkeren, Renée A. Douma, Daisy Rusch, Suat Simsek, Suat Simsek, Limmie Liu, Ruud S. Kootte, Caroline E. Wyers, Richard G. IJzerman, Joop P. van den Bergh, Coen D. A. Stehouwer, Max Nieuwdorp, Kasper W. ter Horst, Mireille J. Serlie

Format: Article
Diterbitkan: Frontiers Media S.A. 2021-12-01

Deskripsi

ObjectiveTo evaluate the association between overweight and obesity on the clinical course and outcomes in patients hospitalized with COVID-19.DesignRetrospective, observational cohort study.MethodsWe performed a multicenter, retrospective, observational cohort study of hospitalized COVID-19 patients to evaluate the associations between overweight and obesity on the clinical course and outcomes.ResultsOut of 1634 hospitalized COVID-19 patients, 473 (28.9%) had normal weight, 669 (40.9%) were overweight, and 492 (30.1%) were obese. Patients who were overweight or had obesity were younger, and there were more women in the obese group. Normal-weight patients more often had pre-existing conditions such as malignancy, or were organ recipients. During admission, patients who were overweight or had obesity had an increased probability of acute respiratory distress syndrome [OR 1.70 (1.26-2.30) and 1.40 (1.01-1.96)], respectively and acute kidney failure [OR 2.29 (1.28-3.76) and 1.92 (1.06-3.48)], respectively. Length of hospital stay was similar between groups. The overall in-hospital mortality rate was 27.7%, and multivariate logistic regression analyses showed that overweight and obesity were not associated with increased mortality compared to normal-weight patients.ConclusionIn this study, overweight and obesity were associated with acute respiratory distress syndrome and acute kidney injury, but not with in-hospital mortality nor length of hospital stay.