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Team-based research is not an innovative concept; however, the current models of team research are based principally on self-formed teams with a defined duration. Current trends seem to point toward the development of administratively designed multidisciplinary teams. Although this seems logical, minimal guidelines exist to aid in team development or evaluate team outcomes. Critical processes in a team-based research atmosphere have not been identified, much less described, and strategies for successful implementation have not been proposed. The strength of this approach can be summarized as a unified focus during the course of problem definition and solution. Many trade-offs and obstacles are apparent with a broad-based focus. Chief obstacles and barriers include sustaining the balance between remaining small in size and focused on a problem while fitting into the departmental culture. Internal administrative support is mandatory for building a successful multidisciplinary research team. The required interdependence of multidisciplinary team research requires administrators, as well as peers, to recognize the positive value of each contribution.