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The Taguchi design of experiments (DOE) approach is adopted here to evaluate the impact of<br />effective factors such as nanoparticles type, nanoparticles to model solution mass ratio, asphaltene<br />structure, and temperature on asphaltene adsorption equilibrium. Herein, the toluene-asphaltene<br />solution model is applied. Three commercially nanoparticles (SiO2, Al2O3, and TiO2) are used.<br />Asphaltene characterizations are carried out by X-ray diffraction (XRD) analysis. It is found that the<br />nanoparticle type and asphaltene structure with a respective influence of 48.5% and 3.11% have the<br />maximum and minimum contribution on the amount of adsorbed asphaltene at the selected levels<br />respectively. Aluminum oxide nanoparticle has the maximum and silicon oxide nanoparticle shows<br />the minimum adsorption. The temperature has no statistical significance. Asphaltenes with higher<br />aromaticity have more tendencies for adsorption on nanoparticles.