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The genus <i>Biscogniauxia</i>, a member of the family Xylariaceae, is distributed worldwide with more than 50 recognized taxa. <i>Biscogniauxia</i> species is known as a plant pathogen, typically acting as a parasite on tree bark, although certain members of this genus also function as endophytic microorganisms. <i>Biscogniauxia</i> endophytic strain has received attention in many cases, which includes constituent research leading to the discovery of various bioactive secondary metabolites. Currently, there are a total of 115 chemical compounds belonging to the class of secondary metabolites, and among these compounds, fatty acids have been identified. In addition, the strong pharmacological agents of this genus are (3a<i>S</i>,4a<i>R</i>,8a<i>S</i>,9a<i>R</i>)-3a-hydroxy-8a-methyl-3,5-dimethylenedecahydronaphto [2,3-<i>b</i>]furan-2(3<i>H</i>)-one (HDFO) (antifungal), biscopyran (phytotoxic activity), reticulol (antioxidant), biscogniazaphilone A and B (antimycobacterial), and biscogniauxone (Enzyme GSK3 inhibitor). This comprehensive research contributes significantly to the potential discovery of novel drugs produced by <i>Biscogniauxia</i> and holds promise for future development. Importantly, it represents the first-ever review of natural products originating from the <i>Biscogniauxia</i> genus.