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Giant-cell tumors (GCTs) or osteoclastomas of the bone are locally aggressive tumors with tendency for local recurrence. The tumors show predilection for women with majority of patients in the third or fourth decades of life. Usually, GCT involves the ends of long bones. The most common sites involved are the distal femur, proximal tibia, distal radius, and the sacrum. Unusual locations such as scapula, skull, and small bones of the hand and feet are involved in approximately 2% of cases. Involvement of metacarpal has been reported in few cases so far. We report a case of GCT in the first metacarpal in a 16-year-old girl. We discuss the clinical, pathological, and radiological features. Awareness of this location is important, and GCT should be included in the differential diagnosis of expansile lesions of the small bones of the hand.