ATRX, DAXX or MEN1 mutant pancreatic neuroendocrine tumors are a distinct alpha-cell signature subgroup
oleh: Chang S. Chan, Saurabh V. Laddha, Peter W. Lewis, Matthew S. Koletsky, Kenneth Robzyk, Edaise Da Silva, Paula J. Torres, Brian R. Untch, Janet Li, Promita Bose, Timothy A. Chan, David S. Klimstra, C. David Allis, Laura H. Tang
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2018-10-01 |
Deskripsi
In pancreatic neuroendocrine tumors (PanNETs) ATRX, DAXX, and MEN1 are commonly mutated (A-D-M mutant PanNETs). Here, the authors find in a cohort of PanNETS 58% are A-D-M mutant PanNETs, with a worse clinical outcome and differences in gene expression and methylation compared to A-D-M wild type cases- these gene expression differences suggest that A-D-M mutant PanNETs potentially originate from a cell type similar to alpha cells.