Find in Library

NLRP3 inflammasome is an intracellular multi-protein complex that can be activated by a variety of pathogens and endogenous pathogenic molecules and then leads to the release of cytokines, including interleukin-1β(IL-1β), IL-18 and causes, pyroptosis. It plays an important role in innate immunity. However, the over activation may lead chronic inflammation, which is closely related to the pathogenesis and development of numerous major diseases. Therefore, further investigation on the activation mechanisms of NLRP3 inflammasome is of great significance for the development of its specific inhibitors and the treatment of NLRP3-related diseases.