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<b>Background</b> : The number of physician scientists worldwide is decreasing. A review of literature suggests paucity of information examining perceptions and practices towards research among medical undergraduate students in India. Hence, this study was undertaken. <b> Objectives</b> : To understand (a) the awareness, skills, perceptions and practices among undergraduate (UG) medical students towards research, (b) the factors responsible for willingness to take up research as a career among the undergraduates. <b> Material and Methods</b> : This is a questionnaire-based qualitative study. This study was conducted in Kasturba Medical College, Mangalore. A pre-tested questionnaire examining their awareness, perceptions and practices towards research in medical field was used. Consent was obtained from the Dean of the College and student participation was voluntary. <b> Analysis</b> : The information was analyzed using SPSS version 11. Univariate and Multivariate analyses were done to know the willingness to consider research as a career. <b> Results</b> : A total of 471 students responded giving a response rate of 55.41&#x0025;. Nearly 70&#x0025; were aware about research though their level of awareness varied. Various skills of conducting research were known to 47&#x0025; of the students. Most (76&#x0025;) were part of a research team mainly as a part of the medical curriculum, a few (8.3&#x0025;) were confident of research as a career option. The multivariate reveals that those with good skill and students who involved in research in addition to curriculum were more likely to take up research as career option/would continue to do research in future. <b> Conclusions</b> : Good training and student support programs exclusively for research would motivate students to opt for research careers.