Find in Library
Search millions of books, articles, and more
Indexed Open Access Databases
Mechanism of phase condensation for chromosome architecture and function
oleh: Jeongveen Park, Jeong-Jun Kim, Je-Kyung Ryu
Format: | Article |
---|---|
Diterbitkan: | Nature Publishing Group 2024-04-01 |
Deskripsi
Abstract Chromosomal phase separation is involved in a broad spectrum of chromosome organization and functional processes. Nonetheless, the intricacy of this process has left its molecular mechanism unclear. Here, we introduce the principles governing phase separation and its connections to physiological roles in this context. Our primary focus is contrasting two phase separation mechanisms: self-association-induced phase separation (SIPS) and bridging-induced phase separation (BIPS). We provide a comprehensive discussion of the distinct features characterizing these mechanisms and offer illustrative examples that suggest their broad applicability. With a detailed understanding of these mechanisms, we explore their associations with nucleosomes and chromosomal biological functions. This comprehensive review contributes to the exploration of uncharted territory in the intricate interplay between chromosome architecture and function.