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Introduction: Musculoskeletal disorders can be associated with various physical and psychological disorders for the affected individuals. Objectives: In the present study, the prevalence of musculoskeletal disorders among nurses working in emergency departments was studied. Methods: The study was conducted in three teaching hospitals affiliated to Qazvin University of Medical Sciences (2018-2019). Musculoskeletal disorders were studied among 100 nurses working in the emergency department using Nordic questionnaire. Collected data were then analyzed using SPSS version 16. Results: A total number of 100 nurses participated in this study. Among them, 83 of them were female. The mean age of participants was 28.7±6.2 years. The most prevalent musculoskeletal disorders were in the lumbar region (67%) and then in the neck, knees and shoulders, respectively. The results also showed that rest, decreased activity, leaving the workplace, or inability to perform activity at work or home was occurred after musculoskeletal disorders (30%). No significant relationship between demographic variables and the prevalence of musculoskeletal disorders was observed (p>0.05). Conclusion: The present study showed that prevalence of musculoskeletal disorders among emergency nurses is high. Given the fact that a significant portion of hospital care services is provided by nurses, their physical health should always be considered by managers and policy makers and the necessary measures should be taken into account in this regard.