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Abstract We extend the known Universal One-Loop Effective Action (UOLEA) by all operators which involve scalars and fermions, not including contributions arising from open covariant derivatives. Our generic analytic expressions for the one-loop Wilson coefficients of effective operators up to dimension six allow for an application of the UOLEA to a broader class of UV-complete models. We apply our generic results to various effective theories of supersymmetric models, where different supersymmetric particles are integrated out at a high mass scale.