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Objectives: We aimed to describe and compare the complications associated with different percutaneous radiologic gastrostomy (PRG) techniques. Methods: A retrospective and prospective observational study was conducted. Patients who underwent a PRG between 1995–2020 were included. Techniques: A pigtail catheter was used until 2003, a balloon catheter without pexy was used between 2003–2009 and a balloon catheter with gastropexy was used between 2015–2021. For the comparison of proportions, X² tests or Fisher’s test were used when necessary. Univariate analysis was performed to study the risk factors for PRG-associated complications. Results: <i>n</i> = 330 (pigtail = 114, balloon-type without pexy = 28, balloon-type with pexy = 188). The most frequent indication was head and neck cancer. The number of patients with complications was 44 (38.5%), 11 (39.2%) and 54 (28,7%), respectively. There were seven (25%) cases of peritonitis in the balloon-type without-pexy group and 1 (0.5%) in the balloon-type with-pexy group, the latter being the only patient who died in the total number of patients (0.3%). Two (1%) patients of the balloon-type with-pexy group presented with gastrocolic fistula. The rest of the complications were minor. Conclusions: The most frequent complications associated with the administration of enteral nutrition through PRG were minor and the implementation of the balloon-type technique with pexy has led to a decrease in them.