Synthesis of 1<i>H</i>-3-{4-[(3-Dimethylaminopropyl)aminomethyl]phenyl}-2-phenylindole and Evaluation of Its Antiprotozoal Activity
oleh: Jean Guillon, Clotilde Boudot, Anita Cohen, Solène Savrimoutou, Sandra Rubio, Vittoria Milano, Mathieu Marchivie, Nadine Azas, Catherine Mullié, Pascal Sonnet, Bertrand Courtioux
| Format: | Article |
|---|---|
| Diterbitkan: | MDPI AG 2019-05-01 |
Deskripsi
1<i>H</i>-3-{4-[(3-Dimethylaminopropyl)aminomethyl]phenyl}-2-phenylindole was synthesized via a multi-step pathway starting from 2-iodoaniline. Structure characterization of this new indole compound was achieved by <sup>1</sup>H-NMR, <sup>13</sup>C-NMR and ESI-MS spectral analysis. The title compound was screened in vitro against three protozoan parasites (<i>Plasmodium falciparum</i>, <i>Leishmania donovani</i> and <i>Trypanosoma brucei brucei</i>). Biological results showed antiparasitic activity with IC<sub>50</sub> values in the μM range.