CARD9 negatively regulates NLRP3-induced IL-1β production on Salmonella infection of macrophages
oleh: Milton Pereira, Panagiotis Tourlomousis, John Wright, Tom P. Monie, Clare E. Bryant
| Format: | Article |
|---|---|
| Diterbitkan: | Nature Portfolio 2016-09-01 |
Deskripsi
IL-1β is important for control of bacterial infections, but when deregulated can lead to excessive inflammation. The authors show that the adaptor protein CARD9 suppresses levels of IL-1β and is downregulated during S. Typhimuriuminfection, thus facilitating an inflammatory response